Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium.

ABSTRACT: Cell division, movement and differentiation contribute to pattern formation in developing tissues. This is the case in the vertebrate neural tube, in which neurons differentiate in a characteristic pattern from a highly dynamic proliferating pseudostratified epithelium. To investigate how progenitor proliferation and differentiation affect cell arrangement and growth of the neural tube, we used experimental measurements to develop a mechanical model of the apical surface of the neuroepithelium that incorporates the effect of interkinetic nuclear movement and spatially varying rates of neuronal differentiation. Simulations predict that tissue growth and the shape of lineage-related clones of cells differ with the rate of differentiation. Growth is isotropic in regions of high differentiatio

SUBMITTER: Guerrero P 

PROVIDER: S-EPMC6918779 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature