Ontology highlight
ABSTRACT:
SUBMITTER: Sulahian R
PROVIDER: S-EPMC6918830 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell reports 20191001 1
The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 screens in the presence of a MEK1/2 inhibitor (MEKi) in KRAS-mutant pancreatic and lung cancer cell lines and identified genes that cooperate with MEK inhibition. While we observed heterogeneity in genetic modifiers of MEKi sensitivity across cell lines, several ...[more]