Activatable Small-Molecule Hydrogen Sulfide Donors.

ABSTRACT: Significance: Hydrogen sulfide (H₂S) is an important biological signaling molecule involved in many physiological processes. These diverse roles have led researchers to develop contemporary methods to deliver H₂S under physiologically relevant conditions and in response to various stimuli. Recent Advances: Different small-molecule donors have been developed that release H₂S under various conditions. Key examples include donors activated in response to hydrolysis, to endogenous species, such as thiols, reactive oxygen species, and enzymes, and to external stimuli, such as photoactivation and bio-orthogonal chemistry. In addition, an alternative approach to release H₂S has utilized the catalyzed hydrolysis of carbonyl su

SUBMITTER: Levinn CM 

PROVIDER: S-EPMC6918874 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature