Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.

ABSTRACT: Asthma is a heterogeneous disease that results from the complex interaction between genetic factors and environmental exposures that occur at critical periods throughout life. It seems plausible to regard childhood-onset and adult-onset asthma as different entities, each with a different pathophysiology, trajectory, and outcome. This review provides an overview about the role of genetics and gene-environment interactions in these two conditions. Looking at the genetic overlap between childhood and adult onset disease gives one window into whether there is a correlation, as well as to mechanism. A second window is offered by the genetics of the relationship between each type of asthma and other phenotypes e.g., obesity, chronic obstructive pulmonary disease (COPD), atopy, vitamin D levels,

SUBMITTER: Morales E 

PROVIDER: S-EPMC6918916 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature