Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles.

ABSTRACT: We previously observed an association between mode of delivery and brain mitochondrial mechanisms in pups. We also showed that mitochondrial processes impact adult behavior. However, no experimental data is available to causally connect mode of delivery with cellular processes of neurons in the cerebral cortex and adult behavior. Here we show that surgical delivery of pups alters mitochondrial dynamics and spine synapses of layer 3 pyramidal neurons of the prefrontal cortex compared to the values of mice delivered vaginally. These alterations in ultrastructure seen in adult mice delivered surgically were associated with the development of behavioral phenotypes resembling those characteristic of animal models of psychiatric illness. This included impaired performance in prepulse inhibition

SUBMITTER: Taylor-Giorlando M 

PROVIDER: S-EPMC6918927 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature