Selenium and Selenoprotein P Deficiency Correlates With Complications and Adverse Outcome After Major Trauma.

ABSTRACT:

Background

A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period.

Patients and methods

Twenty-four patients after major trauma (ISS ≥16) were included at our level one trauma center. Se supplementation ever during the 90-day observation period was defined as an exclusion criterion. Serum samples were drawn within less than 60 min after trauma, and after 6 h, 12 h, 24 h, 48 h,

SUBMITTER: Braunstein M 

PROVIDER: S-EPMC6919221 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature