Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia.

ABSTRACT:

Background

FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed.

Material and methods

We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical a

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6919540 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature