Modulators of hormonal response regulate temporal fate specification in the Drosophila brain.

ABSTRACT: Neuronal diversity is at the core of the complex processing operated by the nervous system supporting fundamental functions such as sensory perception, motor control or memory formation. A small number of progenitors guarantee the production of this neuronal diversity, with each progenitor giving origin to different neuronal types over time. How a progenitor sequentially produces neurons of different fates and the impact of extrinsic signals conveying information about developmental progress or environmental conditions on this process represent key, but elusive questions. Each of the four progenitors of the Drosophila mushroom body (MB) sequentially gives rise to the MB neuron subtypes. The temporal fate determination pattern of MB neurons can be influenced by extrinsic cues, conveyed by t

SUBMITTER: Marchetti G 

PROVIDER: S-EPMC6919624 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature