Opioid-Induced Constipation in Oncological Patients: New Strategies of Management.

ABSTRACT:

Opinion statement

Cancer-associated pain has traditionally been treated with opioid analgesics, often in escalating doses. Opioid-induced constipation (OIC) is a common problem associated with chronic use of opioid analgesics. Typical treatment strategies to alleviate constipation are based on dietary changes, exercise, and laxatives. However, laxatives have a nonspecific action and do not target underlying mechanisms of OIC. This article will review prevalent, clinical presentation and recommendations for the treatment of OIC. An independent literature search was carried out by the authors. We reviewed the literature for randomized controlled trials that studied the efficacy of laxatives, naloxone, and naloxegol in treating OIC. Newer strategies addressing the causal pathophysiolo

SUBMITTER: Mesia R 

PROVIDER: S-EPMC6920224 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature