Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.

ABSTRACT:

Background and objectives

The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.

Methods

Early PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS- groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.

Results

EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positi

SUBMITTER: Ooi LQR 

PROVIDER: S-EPMC6920242 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature