FDG uptake tracks the oxidative damage in diabetic skeletal muscle: An experimental study.

ABSTRACT:

Objectives

The present study aims to verify the relationship between glucose consumption and uptake of ¹⁸F-2-deoxy-glucose (FDG) in the skeletal muscle (SM) of experimental models of streptozotocin-induced diabetes mellitus (STZ-DM).

Methods

The study included 36 Balb/c mice. Two weeks after intraperitoneal administration of saline (control group, n = 18) or 150 mg streptozotocin (STZ-DM group, n = 18), the two cohorts were submitted to an oral glucose tolerance test and were further subdivided into three groups (n = 6 each): untreated and treated with metformin (MTF) at low or high doses (10 or 750 mg/kg daily, respectively). Two weeks thereafter, all mice were submitted to dynamic micro-positron emission tomography (PET) imaging after prolonged fasting. After sa

SUBMITTER: Bauckneht M 

PROVIDER: S-EPMC6920267 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature