Pharmacological polysulfide suppresses glucose-stimulated insulin secretion in an ATP-sensitive potassium channel-dependent manner.

ABSTRACT: Hydrogen sulfide (H₂S) is an endogenous gaseous transmitter synthesized in various cell types. It is well established that H₂S functions in many physiological processes, including the relaxation of vascular smooth muscle, mediation of neurotransmission, regulation of inflammation, and modulation of insulin signaling. In recent years, it has been revealed that polysulfides, substances with a varying number of sulfur atoms (H₂Sn), are generated endogenously from H₂S in the presence of oxygen. A series of studies describes that sulfane sulfur has the unique ability to bind reversibly to other sulfur atoms to form hydropersulfides and polysulfides, and that polysulfides activate ion channels and promote calcium influx. Furthermore, polysulfides regul

SUBMITTER: Shoji T 

PROVIDER: S-EPMC6920347 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature