A causal relationship between cigarette smoking and type 2 diabetes mellitus: A Mendelian randomization study.

ABSTRACT: The causality between smoking and type 2 diabetes is unclear. We conducted a two-sample Mendelian randomization study to explore the causal relationship between smoking initiation and type 2 diabetes. Summary-level data for type 2 diabetes were obtained from a meta-analysis of 32 genome-wide association studies (DIAbetes Genetics Replication And Meta-analysis consortium), which included 898 130 individuals of European ancestry. Totally, 377 single-nucleotide polymorphisms associated with smoking initiation at genome wide significance threshold (p < 5 × 10^-8) were identified from the hitherto largest genome-wide association study on smoking. The inverse-variance weighted, weighted median, MR-Egger regression, and MR-PRESSO approaches were used to analyze the data. Genetically pre

SUBMITTER: Yuan S 

PROVIDER: S-EPMC6920406 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature