Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice.

ABSTRACT: Schizophyllum commune is a ubiquitous basidiomycetous fungus typically found across the world, which has been detected in indoor and outdoor air. Some studies indicated that sensitization to S. commune is correlated with asthma severity in patients. Patients with chronic severe or acute fatal asthma have neutrophil-dominant airway inflammation. We hypothesized that S. commune can exacerbate asthma. To test this hypothesis, we evaluated the direct immunomodulatory activities of S. commune in allergic airway inflammation induced by non-fungal sensitization. Ovalbumin (OVA)-induced asthma model mice were generated using wild-type (WT) and Il-17a^-/-Il-17f^-/- mice that were intratracheally exposed to S. commune, then immune responses in the lungs were assessed after 24 h.

SUBMITTER: Hanashiro J 

PROVIDER: S-EPMC6920419 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature