The CHD Protein, Kismet, is Important for the Recycling of Synaptic Vesicles during Endocytosis.

ABSTRACT: Chromatin remodeling proteins of the chromodomain DNA-binding protein family, CHD7 and CHD8, mediate early neurodevelopmental events including neural migration and differentiation. As such, mutations in either protein can lead to neurodevelopmental disorders. How chromatin remodeling proteins influence the activity of mature synapses, however, is relatively unexplored. A critical feature of mature neurons is well-regulated endocytosis, which is vital for synaptic function to recycle membrane and synaptic proteins enabling the continued release of synaptic vesicles. Here we show that Kismet, the Drosophila homolog of CHD7 and CHD8, regulates endocytosis. Kismet positively influenced transcript levels and bound to dap160 and endophilin B transcription start sites and promoters in whole nervo

SUBMITTER: Latcheva NK 

PROVIDER: S-EPMC6920434 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature