GEAMP, a novel gastroesophageal junction carcinoma cell line derived from a malignant pleural effusion.

ABSTRACT: Gastroesophageal junction (GEJ) cancer remains a clinically significant disease in Western countries due to its increasing incidence, which mirrors that of esophageal cancer, and poor prognosis. To develop novel and effective approaches for prevention, early detection, and treatment of patients with GEJ cancer, a better understanding of the mechanisms driving pathogenesis and malignant progression of this disease is required. These efforts have been limited by the small number of available cell lines and appropriate preclinical animal models for in vitro and in vivo studies. We have established and characterized a novel GEJ cancer cell line, GEAMP, derived from the malignant pleural effusion of a previously treated GEJ cancer patient. Comprehensive genetic analyses confirmed a clonal relat

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6920545 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature