Stochastic Expansions Maintain the Clonal Stability of CD8⁺ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus.

ABSTRACT: CMV is an obligate and persistent intracellular pathogen that continually drives the production of highly differentiated virus-specific CD8⁺ T cells in an Ag-dependent manner, a phenomenon known as memory inflation. Extensive proliferation is required to generate and maintain inflationary CD8⁺ T cell populations, which are counterintuitively short-lived and typically exposed to limited amounts of Ag during the chronic phase of infection. An apparent discrepancy therefore exists between the magnitude of expansion and the requirement for ongoing immunogenic stimulation. To address this issue, we explored the clonal dynamics of memory inflation. First, we tracked congenically marked OT-I cell populations in recipient mice infected with murine CMV (MCMV) expressing the co

SUBMITTER: Smith CJ 

PROVIDER: S-EPMC6920548 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature