Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic Infection.

ABSTRACT: T cell dysfunction is a characteristic feature of chronic viral infection and cancer. Recent studies in chronic lymphocytic choriomeningitis virus (LCMV) infection have defined a PD-1⁺ Tcf-1⁺ CD8⁺ T cell subset capable of self-renewal and differentiation into more terminally differentiated cells that downregulate Tcf-1 and express additional inhibitory molecules such as Tim3. Here, we demonstrated that expression of the glycoprotein CD101 divides this terminally differentiated population into two subsets. Stem-like Tcf-1⁺ CD8⁺ T cells initially differentiated into a transitory population of CD101^-Tim3⁺ cells that later converted into CD101⁺ Tim3⁺ cells. Recently generated CD101^-Tim

SUBMITTER: Hudson WH 

PROVIDER: S-EPMC6920571 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature