Associations between vaginal bacteria implicated in HIV acquisition risk and proinflammatory cytokines and chemokines.

ABSTRACT:

Objectives

Recent studies have identified vaginal bacterial taxa associated with increased HIV risk. A possible mechanism to explain these results is that individual taxa differentially promote cervicovaginal inflammation. This study aimed to explore relationships between concentrations of bacteria previously linked to HIV acquisition and vaginal concentrations of proinflammatory cytokines and chemokines.

Methods

In this cross-sectional analysis, concentrations of 17 bacterial taxa and four proinflammatory cytokines (interleukin (IL)-1β, IL-6, IL-10 and tumour necrosis factor alpha (TNFα)) and two proinflammatory chemokines (IL-8 and interferon gamma-induced protein 10) were measured in vaginal swabs collected from 80 HIV-uninfected women. Cytokine and chemokine concentratio

SUBMITTER: Sabo MC 

PROVIDER: S-EPMC6920574 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature