Catecholamines Induce Endoplasmic Reticulum Stress Via Both Alpha and Beta Receptors.

ABSTRACT: Severely burned patients suffer from a hypermetabolic syndrome that can last for years after the injury has resolved. The underlying cause of these metabolic alterations most likely involves the persistent elevated catecholamine levels that follow the surge induced by thermal injury. At the cellular level, endoplasmic reticulum (ER) stress in metabolic tissues is a hallmark observed in patients following burn injury and is associated with several detrimental effects. Therefore, ER stress could be the underlying cellular mechanism of persistent hypermetabolism in burned patients. Here, we show that catecholamines induce ER stress and that adreno-receptor blockers reduce stress responses in the HepG2 hepatocyte cell line. Our results also indicate that norepinephrine (NE) significantly induc

SUBMITTER: Abdullahi A 

PROVIDER: S-EPMC6920607 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature