Global and site-specific analysis of bone in a rat model of spinal cord injury-induced osteoporosis.

ABSTRACT: Micro-Computed Tomography bone analysis is the gold standard method for assessing trabecular and cortical bone microarchitecture in small animal bones. This technique reports morphometric parameters as averages over selected volumes of interest (VOIs). This study proposes the introduction of an additional global 2D morphometric step into the analysis process, that provides a survey of the underlying morphometric variation present throughout both trabecular and cortical bone. The visualisation of these morphometric distributions provides a systematic approach to VOI selection that provides rationale and adds confidence to subsequent 3D morphometric analysis. To test the applicability and value of this methodological addition it was applied to the distal femur of a rat model of spinal cord i

SUBMITTER: Williams JA 

PROVIDER: S-EPMC6920718 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature