Bone Morphogenic Protein 2-Loaded Porous Silicon Carriers for Osteoinductive Implants.

ABSTRACT: Bone morphogenetic proteins (BMPs) are probably the most important growth factors in bone formation and healing. However, the utilization of BMPs in clinical applications is mainly limited due to the protein poor solubility at physiological pH, rapid clearance and relatively short biological half-life. Herein, we develop degradable porous silicon (PSi)-based carriers for sustained delivery of BMP-2. Two different loading approaches are examined, physical adsorption and covalent conjugation, and their effect on the protein loading and release rate is thoroughly studied. The entrapment of the protein within the PSi nanostructures preserved its bioactivity for inducing osteogenic differentiation of rabbit bone marrow mesenchymal stems cells (BM-MSCs). BM-MSCs cultured with the BMP-2 loaded PS

SUBMITTER: Rosenberg M 

PROVIDER: S-EPMC6920899 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature