Antibodies from the Sera of Multiple Sclerosis Patients Efficiently Hydrolyze Five Histones.

ABSTRACT: It is known that intranuclear histones can be pernicious after entering to the extracellular space. In addition, the immunization of animals with exogenous histones leads to systemic inflammatory and toxic reactions. Abzymes-autoantibodies with enzymatic activities-are the distinctive feature of autoimmune diseases and they can be especially dangerous to humans. Here, electrophoretically homogeneous IgGs were isolated from sera of patients with multiple sclerosis (MS) by chromatography on several affinity sorbents. We present evidence that sera of all MS patients contain autoantibodies against histones and 73% of IgGs purified from the sera of 59 MS patients efficiently hydrolyze from one to five histones: H1, H2a, H2b, H3, and H4. The relative average efficiency of the histones hydrolysis

SUBMITTER: Baranova SV 

PROVIDER: S-EPMC6920934 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature