Inflammatory Immune Responses in Patients with Tick-Borne Encephalitis: Dynamics and Association with the Outcome of the Disease.

ABSTRACT: Information on the association of inflammatory immune responses and disease outcome after tick-borne encephalitis (TBE) is limited. In the present study, we assessed the levels of 24 cytokines/chemokines associated with innate and adaptive immune responses in matched serum and cerebrospinal fluid (CSF) samples of 81 patients at first visit, and in serum at follow-up time points. Serum levels of several cytokines/chemokines obtained during the meningoencephalitic phase of TBE differed compared to the levels at a follow-up visit 2 months later; several significant differences were also found in cytokine/chemokine levels in serum at 2 months compared to the last time point, 2-7 years after acute illness. Cytokines/chemokines levels in CSF or serum obtained at the time of acute illness or seru

SUBMITTER: Bogovic P 

PROVIDER: S-EPMC6920956 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature