Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles.

ABSTRACT: Polymeric particles made up of biodegradable and biocompatible polymers such as poly(lactic-co-glycolic acid) (PLGA) are promising tools for several biomedical applications including drug delivery. Particular emphasis is placed on the size and surface functionality of these systems as they are regarded as the main protagonists in dictating the particle behavior in vitro and in vivo. Current methods of manufacturing polymeric drug carriers offer a wide range of achievable particle sizes, however, they are unlikely to accurately control the size while maintaining the same production method and particle uniformity, as well as final production yield. Microfluidics technology has emerged as an efficient tool to manufacture particles in a highly controllable manner. Here, we report on tuning the

SUBMITTER: Operti MC 

PROVIDER: S-EPMC6921086 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature