Taking central nervous system regenerative therapies to the clinic: curing rodents versus nonhuman primates versus humans.

ABSTRACT: The central nervous system is known to have limited regenerative capacity. Not only does this halt the human body's reparative processes after central nervous system lesions, but it also impedes the establishment of effective and safe therapeutic options for such patients. Despite the high prevalence of stroke and spinal cord injury in the general population, these conditions remain incurable and place a heavy burden on patients' families and on society more broadly. Neuroregeneration and neural engineering are diverse biomedical fields that attempt reparative treatments, utilizing stem cells-based strategies, biologically active molecules, nanotechnology, exosomes and highly tunable biodegradable systems (e.g., certain hydrogels). Although there are studies demonstrating promising preclin

SUBMITTER: Tsintou M 

PROVIDER: S-EPMC6921352 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature