Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

ABSTRACT:

Background

Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC incidence rate in Asian populations has significantly increased in recent decades, it is critical to elucidate its molecular features that could lead to OCCC-tailored therapeutic strategies.

Methods

Gene expression profiles of 222 OCCC were analyzed by hierarchical clustering and statistical analyses.

Findings

We identified two OCCC gene expression subtypes: EpiCC-epithelial-like, which is associated with early-stage disease, with a relatively higher rate of

SUBMITTER: Tan TZ 

PROVIDER: S-EPMC6921362 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature