Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.

ABSTRACT:

Background

Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. The underlying molecular mechanisms responsible for the diverse phenotypes of ECs from different organs are not well understood.

Results

To characterize the transcriptomic and epigenomic landscape in the vascular system, we cataloged gene expression and active histone marks in nine types of human ECs (generating 148 genome-wide datasets) and carried out a comprehensive analysis with chromatin interaction data. We developed a robust procedure for comparative epigenome analysis that circumvents variations at the level of the individual and technical noise derive

SUBMITTER: Nakato R 

PROVIDER: S-EPMC6921469 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature