Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles.

ABSTRACT:

Background

Macrophages show versatile functions in innate immunity, infectious diseases, and progression of cancers and cardiovascular diseases. These versatile functions of macrophages are conducted by different macrophage phenotypes classified as classically activated macrophages and alternatively activated macrophages due to different stimuli in the complex in vivo cytokine environment. Dissecting the regulation of macrophage activations will have a significant impact on disease progression and therapeutic strategy. Mathematical modeling of macrophage activation can improve the understanding of this biological process through quantitative analysis and provide guidance to facilitate future experimental design. However, few results have been reported for a complete model of macrop

SUBMITTER: Ramirez R 

PROVIDER: S-EPMC6921543 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature