The scale of neurodegeneration in moderate-to-severe traumatic brain injury: a systematic review protocol.

ABSTRACT:

Background

Our understanding of recovery after moderate-to-severe traumatic brain injury (TBI) has shifted. Until recently, it was presumed that following a period of acute neurological vulnerability, the brain remained stable in the chronic stages of injury. However, recent research has shown neurodegeneration in the chronic stages of moderate-to-severe TBI, challenging the assumption of neurological stability. While there is extensive evidence that neurodegeneration occurs, debate remains regarding the scale and timing. This systematic review will evaluate the scale and timelines of neurodegeneration in adult patients with moderate-to-severe TBI.

Methods

Literature searches will be conducted in six electronic databases (from inception onwards), including MEDLINE, EMBASE, P

SUBMITTER: Sharma B 

PROVIDER: S-EPMC6921548 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature