Nickel-induced transcriptional changes persist  post exposure through epigenetic reprogramming.

ABSTRACT:

Background

Nickel is an occupational and environmental toxicant associated with a number of diseases in humans including pulmonary fibrosis, bronchitis and lung and nasal cancers. Our earlier studies showed that the nickel-exposure-induced genome-wide transcriptional changes, which persist even after the termination of exposure may underlie nickel pathogenesis. However, the mechanisms that drive nickel-induced persistent changes to the transcriptome remain elusive.

Results

To elucidate the mechanisms that underlie nickel-induced long-term transcriptional changes, in this study, we examined the transcriptome and the epigenome of human lung epithelial cells during nickel exposure and after the termination of exposure. We identified two categories of persistently differentially

SUBMITTER: Jose CC 

PROVIDER: S-EPMC6921556 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature