YAP as a key regulator of adipo-osteogenic differentiation in human MSCs.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) are multipotent stem cells that are able to differentiate into several cell types, including cartilage, fat, and bone. As a common progenitor, MSC differentiation has to be tightly regulated to maintain the balance of their differentiation commitment. It has been reported that the decision process of MSCs into fat and bone cells is competing and reciprocal. Several factors have been suggested as critical factors that affect adipo-osteogenic decision, including melatonin and smad4. Yes-associated protein (YAP) is an important effector protein in the Hippo signaling pathway that acts as a transcriptional regulator by activating the transcription of the genes involved in cell proliferation and anti-apoptosis. The non-canonical role of YAP in re

SUBMITTER: Lorthongpanich C 

PROVIDER: S-EPMC6921580 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature