Role of Wybutosine and Mg²⁺ Ions in Modulating the Structure and Function of tRNA^Phe: A Molecular Dynamics Study.

ABSTRACT: Transfer RNA remains to be a mysterious molecule of the cell repertoire. With its modified bases and selectivity of codon recognition, it remains to be flexible inside the ribosomal machinery for smooth and hassle-free protein biosynthesis. Structural changes occurring in tRNA due to the presence or absence of wybutosine, with and without Mg²⁺ ions, have remained a point of interest for structural biologists. Very few studies have come to a conclusion correlating the changes either with the structure and flexibility or with the codon recognition. Considering the above facts, we have implemented molecular modeling methods to address these problems using multiple molecular dynamics (MD) simulations of tRNA^Phe along with codons. Our results highlight some of the earlier

SUBMITTER: Fandilolu PM 

PROVIDER: S-EPMC6921629 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature