Ontology highlight
ABSTRACT:
SUBMITTER: Svendsen JM
PROVIDER: S-EPMC6922003 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cell reports 20191201 10
The germline contains an immortal cell lineage that ensures the faithful transmission of genetic and, in some instances, epigenetic information from one generation to the next. Here, we show that in Caenorhabditis elegans, the small RNA 3'-2'-O-methyltransferase henn-1/HEN1 is required for sustained fertility across generations. In the absence of henn-1, animals become progressively less fertile, becoming sterile after ∼30 generations at 25°C. Sterility in henn-1 mutants is accompanied by severe ...[more]