Plasma protein patterns as comprehensive indicators of health.

ABSTRACT: Proteins are effector molecules that mediate the functions of genes^1,2 and modulate comorbidities^3-10, behaviors and drug treatments¹¹. They represent an enormous potential resource for personalized, systemic and data-driven diagnosis, prevention, monitoring and treatment. However, the concept of using plasma proteins for individualized health assessment across many health conditions simultaneously has not been tested. Here, we show that plasma protein expression patterns strongly encode for multiple different health states, future disease risks and lifestyle behaviors. We developed and validated protein-phenotype models for 11 different health indicators: liver fat, kidney filtration, percentage body fat, visceral fat mass, lean body mass, cardiopulmonary

SUBMITTER: Williams SA 

PROVIDER: S-EPMC6922049 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature