Interleukin-6 gene polymorphisms and susceptibility to liver diseases: A meta-analysis.

ABSTRACT:

Background

Several studies have explored the associations between interleukin-6 (IL-6) gene polymorphisms and the susceptibility to liver diseases, however, results remain ambiguous. The goal of this study was to conduct a meta-analysis to provide more credible evidence.

Methods

Studies identified in the PubMed, Cochrane Library, and EMBASE databases were used to perform a meta-analysis via the STATA software. Pooled odds ratios (OR) were calculated under fixed- and random-effects models to estimate the potential genetic associations.

Results

Twenty-five case-control studies involving 5813 cases and 5298 controls were included in this meta-analysis. Overall, the pooled results suggested that rs1800795 polymorphism was significantly associated with the risk of liver di

SUBMITTER: Wang X 

PROVIDER: S-EPMC6922363 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature