Dengue virus reduces AGPAT1 expression to alter phospholipids and enhance infection in Aedes aegypti.

ABSTRACT: More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its mosquito vectors. DENV is an envelope virus that relies on host lipid membranes for its life-cycle. Here, we characterized how DENV hijacks the mosquito lipidome to identify targets for novel transmission-blocking interventions. To describe metabolic changes throughout the mosquito DENV cycle, we deployed a Liquid chromatography-high resolution mass spectrometry (LC-HRMS) workflow including spectral similarity annotation in cells, midguts and whole mosquitoes at different times post infection. We revealed a major aminophospholipid reconfiguration with an overall early increase, followed by a reduction later in the cycle. We phylogenetically characterized acylglycerol

SUBMITTER: Vial T 

PROVIDER: S-EPMC6922471 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature