Generation of a highly attenuated strain of Pseudomonas aeruginosa for commercial production of alginate.

ABSTRACT: Alginate is an important polysaccharide that is commonly used as a gelling agent in foods, cosmetics and healthcare products. Currently, all alginate used commercially is extracted from brown seaweed. However, with environmental changes such as increasing ocean temperature and the increasing number of biotechnological uses of alginates with specific properties, there is an emerging need for more reliable and customizable sources of alginate. An alternative to seaweed for alginate production is Pseudomonas aeruginosa, a common Gram-negative bacterium that can form alginate-containing biofilms. However, P. aeruginosa is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients. Therefore, we sought to engineer a non-pathogenic P. aeruginosa strain tha

SUBMITTER: Valentine ME 

PROVIDER: S-EPMC6922527 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature