Marine Collagen Substrates for 2D and 3D Ovarian Cancer Cell Systems.

ABSTRACT: A fundamental structural component of extracellular matrix in all connective and interstitial tissue, collagen is the most abundant protein in the human body. To date, mammalian collagens sources represent the golden standard for multiple biomedical applications, while marine-derived collagens have largely been used in industry (food, pharmaceutical, and cosmetic), with little use in research and clinical applications. Herein we demonstrate the effective use Rhizostoma pulmo jellyfish collagen, a source of biocompatible, sustainable collagen for 2D and 3D cell culture, addressing the global drive for technological developments that result in the replacement of animals and their derived products in research. Jellyfish collagen harbors similar structural features mammalian collagen type I, d

SUBMITTER: Paradiso F 

PROVIDER: S-EPMC6923181 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature