More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis.

ABSTRACT: Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types both during physiological immune defense and in pathological circumstances, such as autoimmune diseases including rheumatoid arthritis and multiple sclerosis, inflammatory diseases including atherosclerosis, as well as infectious diseases, obesity, diabetes, and various types of cancer. However, new data suggest that the scope of CCL2's functions may extend beyond its original characterization as a chemoattractant. Emerging evidence shows that it can impact leukocyte behavior, influencing adhesion, polarization, effector molecule secretion, autophagy, killing, and survival. The direction of these CCL2-induced re

SUBMITTER: Gschwandtner M 

PROVIDER: S-EPMC6923224 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature