Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.

ABSTRACT: Exposure of lupus-prone female NZBWF1 mice to respirable crystalline silica (cSiO₂), a known human autoimmune trigger, initiates loss of tolerance, rapid progression of autoimmunity, and early onset of glomerulonephritis. We have previously demonstrated that dietary supplementation with the ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) suppresses autoimmune pathogenesis and nephritis in this unique model of lupus flaring. In this report, we utilized tissues from prior studies to test the hypothesis that DHA consumption interferes with upregulation of critical genes associated with cSiO₂-triggered murine lupus. A NanoString nCounter platform targeting 770 immune-related genes was used to assess the effects cSiO₂ on mRNA signatures over time in fe

SUBMITTER: Benninghoff AD 

PROVIDER: S-EPMC6923248 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature