¹⁸F-Fluorodeoxyglucose positron emission tomography may not visualize radiation pneumonitis.

ABSTRACT:

Background

Radiation pneumonitis is a common and potentially fatal complication of radiotherapy (RT). Some patients with radiation pneumonitis show increases in uptake of fluorodeoxyglucose (FDG) on positron emission tomography (PET), but others do not. The exact relationship between radiation pneumonitis and ¹⁸F-FDG PET findings remains controversial.

Methods

We used an animal model of radiation pneumonitis involving both radiation and simulated bacterial infection in Wistar rats. Treatment groups (10 rats/group) were as follows: control, RT-only, lipopolysaccharide (LPS)-only, and RT+LPS. All rats had micro-PET scans at 7 weeks after RT (or sham). Histologic, immunohistochemical, and biochemical analyses were performed to evaluate potential mechanisms.

Result

SUBMITTER: Guo M 

PROVIDER: S-EPMC6923299 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature