The roles of ANRIL polymorphisms in coronary artery disease: a meta-analysis.

ABSTRACT: The relationship between antisense non-coding RNA (ncRNA) in the INK4 locus (ANRIL) polymorphisms and coronary artery disease (CAD) remains inconclusive. Thus, we conducted this meta-analysis to better evaluate the roles of ANRIL polymorphisms in CAD. Systematic literature search of PubMed, Medline, and Embase was performed to identify potential relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association. Fifteen studies were finally enrolled for analyses. Overall analyses suggested that rs1333040 (dominant model: P<0.0001; recessive model: P<0.0001; allele model: P<0.0001), rs1333049 (dominant model: P=0.02; allele model: P=0.02) and rs2383207 (additive model: P=0.004) polymorphisms were significantly associated with the

SUBMITTER: Hu L 

PROVIDER: S-EPMC6923330 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature