Comprehensive analysis of protein acetyltransferases of human pathogen Mycobacterium tuberculosis.

ABSTRACT: Tuberculosis (TB), a leading infectious disease caused by Mycobacterium tuberculosis strain, takes four human lives every minute globally. Paucity of knowledge on M. tuberculosis virulence and antibiotic resistance is the major challenge for tuberculosis control. We have identified 47 acetyltransferases in the M. tuberculosis, which use diverse substrates including antibiotic, amino acids, and other chemical molecules. Through comparative analysis of the protein file of the virulent M. tuberculosis H37Rv strain and the avirulent M. tuberculosis H37Ra strain, we identified one acetyltransferase that shows significant variations with N-terminal deletion, possibly influencing its physicochemical properties. We also found that one acetyltransferase has three types of post-translation modificat

SUBMITTER: Xie L 

PROVIDER: S-EPMC6923341 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature