Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment.

ABSTRACT: The gut microbiota represents a huge community of microorganisms that play essential roles in immune modulation and homeostasis maintenance. Microbiota transplantation is an important approach to prevent and treat disease as it can inhibit pathogen colonization and positively modulate bacterial composition. However, the development of oral bacterial therapeutics has been restricted by low bioavailability and limited retention in the gastrointestinal tract. Here, we report a simple yet highly efficient method to coat gut microbes via biointerfacial supramolecular self-assembly. Coating can be performed within 15 min by simply vortexing with biocompatible lipids. Bacteria coated with an extra self-assembled lipid membrane exhibit significantly improved survival against environmental assaults

SUBMITTER: Cao Z 

PROVIDER: S-EPMC6923387 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature