Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network.

ABSTRACT:

Objective

To establish an axon regeneration regulatory network for optimal selection, and explore the role of low intensity pulsed ultrasound in the network.

Methods

The axon regeneration regulatory network involving axon regeneration-related proteins NGF, BDNF and PirB was constructed by using GO and KEGG. The maximum possible pathway acting on axon regeneration was screened by Bayesian network theory. The node of low - intensity pulsed ultrasound in NGF - involved axon regeneration network was complemented by combining literature methods.

Results

The NGF, BDNF and PirB-involved axonal regeneration regulatory pathway was successfully constructed. The low intensity pulsed ultrasound played a role in axon regeneration by acting on ERK1/2-CREB pathway and GSK-3β. NGF-Tr

SUBMITTER: Liu C 

PROVIDER: S-EPMC6923491 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature