Circulating acetoacetate is associated with poor prognosis in heart failure patients.

ABSTRACT:

Background

Acetoacetate is used as an alternative energy source in the heart, and has the potential to improve cardiac function. However, the prognostic impact of acetoacetate has not been investigated in heart failure.

Methods

This study enrolled consecutive 615 hospitalized patients with heart failure. We investigated the associations between circulating acetoacetate and clinical characteristics or prognosis in HF patients.

Results

We divided the patients into two groups based on circulating acetoacetate levels (high group: acetoacetate ≥35 µmoL/L, n = 313; and low group: acetoacetate <35 µmoL/L, n = 302). The high group had an older age (68 vs. 65 years, P = 0.003) and higher log brain natriuretic peptide levels (2.43 vs. 2.23, P < 0.001) compared with the low grou

SUBMITTER: Yokokawa T 

PROVIDER: S-EPMC6923508 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature