Dietary patterns and risk of systemic lupus erythematosus in women.

ABSTRACT:

Objective

Dietary intake is a complex exposure and a potential risk factor for systemic lupus erythematosus (SLE) due to its impact on lipid and glucose metabolism, oxidative stress, and the intestinal microbiome. We aimed to test whether a prudent dietary pattern is associated with a lower risk of SLE, and whether a Western dietary pattern is associated with a higher risk of SLE.

Methods

We prospectively investigated two dietary patterns and SLE risk among women in the Nurses' Health Study (NHS, 1984-2014) and Nurses' Health Study II (NHSII, 1991-2015). Food frequency questionnaires were completed every four years. Congruent with prior work in NHS and NHSII, we derived two separate dietary patterns (prudent and Western) using principal component analysis within each cohort.

SUBMITTER: Tedeschi SK 

PROVIDER: S-EPMC6923577 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature