Greater intraindividual variability in neuropsychological performance predicts cognitive impairment in de novo Parkinson's disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a neurodegenerative disorder that commonly results in cognitive impairments and dementia. Intraindividual variability of neuropsychological performance is a sensitive marker of cognitive decline in other neurologic populations. However, studies have not examined the longitudinal utility of intraindividual variability in predicting future cognitive impairments among individuals with PD. In the current study, we hypothesized that increased intraindividual variability would predict future cognitive decline independent of traditional neuropsychological markers of cognitive impairment.

Methods

The sample included 423 newly diagnosed PD patients and 175 healthy controls, who were followed up to 5 years (baseline, first, second, third, fourt

SUBMITTER: Jones JD 

PROVIDER: S-EPMC6923625 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature