Cardiovascular morbidities of obstructive sleep apnea and the role of circulating extracellular vesicles.

ABSTRACT: Obstructive sleep apnea (OSA) is characterized by recurrent upper airway collapse during sleep resulting in impaired blood gas exchange, namely intermittent hypoxia (IH) and hypercapnia, fragmented sleep (SF), increased oxidative stress and systemic inflammation. Among a myriad of potential associated morbidities, OSA has been particularly implicated as mechanistically contributing to the prevalence and severity of cardiovascular diseases (CVD). However, the benefits of continuous positive airway pressure (CPAP), which is generally employed in OSA treatment, to either prevent or improve CVD outcomes remain unconvincing, suggesting that the pathophysiological mechanisms underlying the incremental CVD risk associated with OSA are not clearly understood. One of the challenges in development o

SUBMITTER: Khalyfa A 

PROVIDER: S-EPMC6923690 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature